What is spinal cord stimulation? (Neuromodulation)

Spinal cord stimulation is a type of neuromodulation that uses electrical stimulation of the spinal nerves to change how the nervous system works.

Spinal cord stimulation is a type of neuromodulation that uses electrical stimulation of the spinal nerves to change how the nervous system works.

As a technology, neuromodulation acts directly upon nerves to cause an alteration—or modulation—of nerve activity by delivering electrical or pharmaceutical agents directly to a target area.

Approximately 34,000 patients undergo spinal cord stimulator implants each year to treat or manage chronic pain. First used to treat pain in 1967, spinal cord stimulation (SCS) delivers mild electrical stimulation to nerves along the spinal column, modifying nerve activity to minimize the sensation of pain reaching the brain. The U.S. Food and Drug Administration (FDA) first approved SCS in 1989 to relieve chronic pain from nerve damage in the trunk, arms or legs.

Source material from International Neuromodulation Society.
https://www.neuromodulation.com/spinal-cord-stimulation

In almost every spinal cord injury case, some of the nerves below the point of an injury to the spinal cord go dormant but are still living. Applying an electrical stimulation treatment, in customized patterns, can reawaken those circuits. With rehabilitation therapy to revive and renew the nerve connections, eventually these neural pathways can restore functions and respond to commands once again.

Jack Jablonski Foundation is currently funding a pivotal clinical research trial designed to gain FDA approval for spinal cord stimulation treatment for paralysis recovery using the SCONE device.

2023 – FDA Approval Clinical Trial

2011 – A breakthrough in paralysis recovery.

2014 – Paralysis recovery results shock the world.

2017 – Mayo Clinic is first medical center in the world to validate paralysis recovery.

Today – help us BEAT PARALYSIS. 100% of your gift will advance paralysis recovery treatments.

Neuromodulation is a technology that acts directly upon nerves to cause the alteration—or modulation—of nerve activity by delivering electrical or pharmaceutical agents directly to a target area.

Most frequently, people think of neuromodulation in the context of chronic pain relief. However, there are many neuromodulation applications: deep brain stimulation (DBS) treatment for Parkinson’s disease, sacral nerve stimulation for pelvic disorders and incontinence, and spinal cord stimulation for ischemic disorders (angina, peripheral vascular disease).

Over the past decade, one of the most exciting new areas of neuromodulation application has been the advancement of spinal cord stimulation (SCS) for functional recovery from paralysis.

2011 – Paralysis recovery

2017 – Validating Paralysis Recovery

2023 – FDA Approval

The term neuromodulation refers to the controlled application of energy (usually electrical stimulation) to the nervous system for the purpose of treating a disease or characterizing function.

Neuromodulation works by either actively stimulating nerves to produce a natural biological response or by applying targeted pharmaceutical agents in tiny doses directly to a site of action. In addition, neuromodulation devices can stimulate a response where there was previously none, as in the case of a cochlear implant restoring hearing in a deaf patient.

Neurostimulation devices involve the application of electrodes to the brain, the spinal cord, or peripheral nerves. These precisely placed leads connect via an extension cable to a pulse generator and power source, which generates the necessary electrical stimulation. A low-voltage electrical current passes from the generator to the nerve and can either inhibit pain signals or stimulate neural impulses where they were previously absent.

A non-invasive alternative technique delivers the electrical current using an electrode applied to the skin surface using a patch (transcutaneous electrical stimulation, TES).

JJF has funded clinical research using TES for treatment of paralysis recovery. JJF is currently an FDA pivotal trial to achieve approval of the SpineX SCONE device.

Source material from International Neuromodulation Society.
https://www.neuromodulation.com/about-neuromodulation

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